ABSTRACT
La asociación entre drepanocitosis y enfermedades malignas ha sido reportada desde hace mucho tiempo. Entre ellas, se han diagnosticado, tanto tumores sólidos en diferentes sitios del organismo, como enfermedades hematológicas malignas. En la sobrevida ha incidido, no solo la gravedad de la enfermedad neoplásica, sino también el compromiso orgánico crónico de estos pacientes, en los que la fisiopatogenia de la enfermedad hereditaria condiciona con alta frecuencia un desenlace fatal. Se realiza una revisión actualizada de esta asociación para que constituya una alerta, máxime que ya se conoce la relación casi exclusiva de algunas neoplasias y la hemoglobinopatía S...
Association between sickle cell disease and cancer has been reported for a long time. Among them, solid tumors in different locations of the body and hematological malignances have been diagnosed. Not only the severity of the neoplastic disease but also chronic organ involvement have influenced in patients´survival where the physiopathogenesis of the hereditary disease with high frequency determines a fatal outcome. Our goal is to make an updated review on such association as a warning, considering that the almost exclusive relationship of some cancers and hemoglobinopathy S is already known...
Subject(s)
Humans , Hematologic Neoplasms/etiology , Hematologic Neoplasms/prevention & control , Sickle Cell Trait/complicationsABSTRACT
The number of patients with a previously diagnosed malignancy who need cardiac surgery is increasing. Patients with hematological malignancies represent only 0.38% of all patients undergoing cardiac surgery. The literature in this subset of patients is limited to only a few retrospective case series, with limited number of patients undergoing emergency cardiac surgery. We describe three cases with hematological malignancies namely chronic myelogenous leukemia, acute promyelocytic leukemia and chronic lymphocytic leukemia presenting for coronary artery bypass grafting (CABG). Two patients were taken up for emergency CABG in view of ongoing ischemia, one of them was on preoperative intra-aortic balloon pump support. No mortality was observed. Two patients needed transfusion of blood products which was guided by thromboelastography. One patient developed superficial sternal wound infection requiring antibiotic therapy.
Subject(s)
Adult , Aged , Cardiac Surgical Procedures , Coronary Artery Bypass/methods , Female , Hematologic Neoplasms/etiology , Humans , Leukemia, Myelogenous, Chronic, BCR-ABL Positive , Leukemia, Lymphocytic, Chronic, B-Cell , Leukemia, Promyelocytic, Acute , Male , Patient Care , TransplantsABSTRACT
No abstract available.
Subject(s)
Humans , Male , Middle Aged , Bone Marrow Cells/pathology , Chromosomes, Human, X/genetics , Hematologic Neoplasms/etiology , Immunophenotyping , Karyotyping , Klinefelter Syndrome/complications , Mosaicism , Tomography, X-Ray ComputedABSTRACT
This study aims to describe the pattern of paediatric malignancies in a tertiary hospital in North Eastern Nigeria. This was a retrospective study of all paediatric malignancies diagnosed between June 2000 and May 2006 at the Federal Medical Centre; Gombe; Nigeria. Data were collected from the histopathology and haematology registers; as well as patients' case files and were analyzed. A total of 3;313 children were admitted within the study period. Out of this; 68(2.05) children aged less than 15 years (M:F=1:1) had histologically confirmed malignancies. Malignant lymphomas were the most common (42.65) of all the childhood malignancies; with Burkitt's lymphoma ranking highest (68.97). Burkitt's lymphoma also accounted for 29.41of all the malignancies. Other common malignancies included sarcomas 10(14.71); neurofibromatosis 9(13.24); nephroblastoma 8(11.77); acute lymphoblastic leukaemia 5(7.35) and retinoblastoma 4(5.88). The less common paediatric malignancies were melanoma; invasive lobular breast carcinoma and squamous cell carcinoma of the breast; which together accounted for 4.41. Burkitt's lymphoma is the most frequently diagnosed malignant neoplasm in children at the Federal Medical Centre; Gombe
Subject(s)
Burkitt Lymphoma , Child , Hematologic Neoplasms/diagnosis , Hematologic Neoplasms/etiology , Hematologic Neoplasms/pathology , NigeriaABSTRACT
Un número creciente de publicaciones ha demostrado claramente que la infusión de infusión de linfocitos provenientes del dador original es capaz de reinducir remisiones en pacientes con recaídas luego de un trasplante alogénico de células precursoras hematopoyéticas. También se ha comunicado que la efectividad de la misma varía en las distintas patologías en la que se ha utilizado. Los mejores resultados se obtuvieron en leucemia mieloide crónica, con un rango de remisiones entre 60 y 80 por ciento, mientras que los pacientes con leucemia aguda mieloblástica o síndromes melodisplásicos mostraron porcentajes de remisiones del orden del 20 a 40 por ciento y y pacientes con mieloma múltiple un nível de respuestas próximo a 40 por ciento. En cambio en leucemia aguda linfoblástica los resultados han sido por lo general desalentadores, con un rango de respuestas de apenas 10-20 por ciento y aun inferiores en algunas series. Dada la eficacia de las ILD en ciertas recaidas hematológicas post trasplante alogénico como se expondrá en detalle en esta revisión, es justificado anticipar la extensión de su indicación a pacientes recaídos no trasplantados y como terapia de mantenimiento de la remision obtenida por quimioterapia convencional o a altas dosis.
Subject(s)
Humans , Hematologic Neoplasms/etiology , Hematologic Neoplasms/therapy , Hematopoietic Stem Cell Transplantation/adverse effects , Leukemia, Myelogenous, Chronic, BCR-ABL Positive/therapy , Lymphocyte Transfusion/methods , Killer Cells, Natural/immunology , Multiple Myeloma/therapy , Recurrence , T-Lymphocytes/immunology , Tumor Lysis Syndrome/immunologyABSTRACT
A vagotomia subdiafragmática seletiva interfere com a homeostasia glicêmica no modelo experimental animal estudado. Verificou-se que a interrupçäo do ramo vagal anterior (hepático) ou posterior (pancreático) determina elevaçäo da glicemia tanto em ratos avaliados agudamente (15 dias de pós-operatório) quanto cronicamente (60 dias de pós-operatório). Adicionalmente, observou-se que a vagotomia posterior exerce um efeito anterior na fase aguda, evidência que desaparece no grupo crônico. Entretanto, ocorre uma tendência de reduçäo da glicemia nos ratos avaliados cronicamente (60 dias de pós-operatório) em relaçäo aos animais do experimento agudo (15 dias de pós-operatório)